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. 2014 Dec 24;9:241–272. doi: 10.2147/DDDT.S71106

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of Coff/Caff plus Mel on the extracellular Aβ40/42 levels in N2a/APP cells treated with regimen 2.

Notes: N2a/APP cells were treated with Coff (A and B) or Caff (C and D) at 10 μM, plus Mel at 1, 5, or 10 μM for 24 hours, from 7 am to 7 am the next day. The extracellular level of Aβ40/42 was determined by ELISA. **P<0.01 and ***P<0.001, by one-way ANOVA.

Abbreviations: Aβ, amyloid-β; ANOVA, analysis of variance; APP, amyloid precursor protein; Caff, caffeine; Coff, coffee; ELISA, enzyme-linked immunosorbent assay; Mel, melatonin; N2a, Neuro-2a.