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. 2014 Dec 24;9:241–272. doi: 10.2147/DDDT.S71106

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of Coff/Caff plus Mel on the extracellular Aβ40/42 levels in N2a/APP cells treated with Regimen 3.

Notes: N2a/APP cells with 10 μM Coff (A–D) or Caff (E–H) for 12 hours or 24 hours, followed by 10 μM Mel for 12 or 24 hours for 5 consecutive days. The extracellular level of Aβ40/42 was determined by ELISA. *P<0.05 and ***P<0.001, by one-way ANOVA.

Abbreviations: Aβ, amyloid-β; ANOVA, analysis of variance; APP, amyloid precursor protein; Caff, caffeine; Coff, coffee; ELISA, enzyme-linked immunosorbent assay; Mel, melatonin; N2a, Neuro-2a.

Effects of Coff/Caff plus Mel on the extracellular Aβ40/42 levels in N2a/APP cells treated with Regimen 3.

Notes: N2a/APP cells with 10 μM Coff (A–D) or Caff (E–H) for 12 hours or 24 hours, followed by 10 μM Mel for 12 or 24 hours for 5 consecutive days. The extracellular level of Aβ40/42 was determined by ELISA. *P<0.05 and ***P<0.001, by one-way ANOVA.

Abbreviations: Aβ, amyloid-β; ANOVA, analysis of variance; APP, amyloid precursor protein; Caff, caffeine; Coff, coffee; ELISA, enzyme-linked immunosorbent assay; Mel, melatonin; N2a, Neuro-2a.