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Time to first breakthrough HE event during placebo treatment in the RCT and during rifaximin treatment in OLM study. Open circles and open triangles represent censored data. *Event rate was calculated for 168 days of the RCT and the first 168 days in the OLM study. HE, hepatic encephalopathy; OLM, open-label maintenance; RCT, randomised, controlled trial.
