Table 1.

Reported effects of bumetanide in in vivo animal models of neonatal seizures

Dose (mg/kg i.p.)	Species	Age	Model	Reported effect	Behavioral analysis	EEG analysis	References
0.1–0.2	Rat	P9-12	Kainate	Anticonvulsanta	No	Yes	Dzhala et al.19
0.15–0.3	Rat	P10	Hypoxia	No effect	Yes	Yes	Cleary et al.35
0.2–2.5	Rat	P7, P18	PTZ	No effect	Yes	No	Mares94
0.2–0.5	Rat	P12	PTZ	No effect	Yes	No
1	Rat	P12	PTZ	Anticonvulsant	Yes	No
2.5	Rat	P12	PTZ	Proconvulsant	Yes	No
0.5b	Rat	P11	Kindled ADT	Anticonvulsant	Yes	Yes	Mazarati et al.93
	Rat	P14, P21	Kindled ADT	No effect	Yes	Yes
1.8	Rat	P4-9	Sevoflurane	Anticonvulsant	No	Yesc	Edwards et al.90
1.8	Rat	P5-9	Flurothyl	No effect	No	Yes	Minlebaev and Khazipov91
0.1 (daily P11-P60)d	Rat	–	Hyperthermia at P11	Decreased susceptibility to PC-induced seizures at P60	Yes	Yes	Koyama et al.96
2 (daily P1-5)	Mouse	–	Hyperthermia at P17	Proconvulsant	Yes	No	Vargas et al.95

ADT, afterdischarge threshold; PC, pilocarpine; PTZ, pentylenetetrazole.

^aAnticonvulsant effect deduced from EEG power.

^bAdministered already during kindling.

^cUnder anesthesia.

^dBumetanide was administered after hyperthermia.