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. Author manuscript; available in PMC: 2015 Jan 5.
Published in final edited form as: Transfus Med Rev. 2013 Oct 3;27(4):241–248. doi: 10.1016/j.tmrv.2013.08.002

Figure 1. Molecular Nature of mHAs Consisting of Peptide/MHC complexes.

Figure 1

(A) Immune Response to Pathogens. Pathogens are consumed by antigen presenting cells, proteins from infectious microbes are processed into peptides, and the peptides are presented by MHC I and MHC II. T cell receptors from CD4 and CD8 T cells recognize peptide/MHCII and peptide/MHCI complexes, respectively. (B, C) Molecular Basis of mHA alloantigens. Donor polymorphisms (in this case single amino acid changes- indicated by red and green boxes) result in variant peptides presented by MHC. The depicted cartoons are not intended to indicate that the same peptide is presented by MHC I and MHC II.