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RLS epistasis to determine the relative roles of SAGA and SLIK in sgf73Δ and ubp8Δ lifespan extension. SAGA-specific component SPT8 is necessary for the extended RLS of (A) sgf73Δ and (B) ubp8Δ while neither PEP4, the protease necessary for processing of the SLIK-specific form of Spt7 (C, D), nor SLIK– specific component RTG2 (E) are necessary. Legends show (mean RLS, number of mother cells scored). See also Supplemental Figure S4.
