Table 2.
Concentration [μm] required for maximal stabilization in the FRET-melting assays.
| Ligand | Duplex[a] | H-Telo | c-kit1 | c-kit2 | c-myc | bcl2 | k-ras |
|---|---|---|---|---|---|---|---|
| 1 | 6.3 | 4.1 | 2.9 | 1.6 | 8.1 | 4.6 | 6.5 |
| 2 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 3 | 9.7 | 4.4 | 4.3 | 2.9 | 2.1 | 4.7 | 9.0 |
| 4 | 6.10 | 0.36 | 0.34 | 0.8 | 0.34 | 0.56 | 0.69 |
| 5 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 6 | >10 | 1.41 | 6.01 | 5.3 | 1.32 | 2.29 | >10 |
| 7 | 4.70 | 0.92 | 1.94 | 2.0 | 1.07 | 1.23 | 6.83 |
| 8 | 5.23 | 1.25 | 3.69 | 3.1 | 0.85 | 3.09 | 6.42 |
| 9 | >10 | 2.4 | 3.8 | 5.4 | 2.2 | 2.1 | 4.2 |
| 10 | 6.77 | 1.18 | 4.39 | 1.3 | 0.77 | 1.58 | 5.57 |
| 11 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 12 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
[a]
Duplex formed by two complementary strands linked by a hexa(ethylene glycol) loop.