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. Author manuscript; available in PMC: 2015 Jan 5.
Published in final edited form as: Bone. 2014 Sep 3;69:12–22. doi: 10.1016/j.bone.2014.08.016

Fig. 4.

Fig. 4

X-ray and histological evaluations of the images of metaphyseal fracture healing. A, X-ray images of tibial fractures of the metaphyseal fracture study exhibited fracture healing in chGRKO and CTR mice; B, representative histological images of tibial fractures of chGRKO and CTR mice from week 1 to week 4. Safranin O/fast green staining exhibited larger cartilaginous callus in chGRKO mice than CTR mice at weeks 1 and 2, while tibiae harvested at weeks 3 and 4 only demonstrated woven bone; C, histomorphometric analysis confirmed that chGRKO mice displayed greater cartilaginous callus area 1 and 2 week post-surgery when compared with CTR mice.