Table 3.
Predicted early functional changes in case group that had MIE.
| Functions annotation | P value | Activation z- score |
# of genes |
|---|---|---|---|
| Increased | |||
| Chemotaxis | <0.001 | 3.924 | 55 |
| Chemotaxis of cells | <0.001 | 3.924 | 54 |
| Homing of cells | <0.001 | 3.815 | 59 |
| Chemotaxis of leukocytes | <0.001 | 3.795 | 37 |
| Chemotaxis of phagocytes | <0.001 | 3.546 | 30 |
| Chemotaxis of myeloid cells | <0.001 | 3.501 | 29 |
| Homing of leukocytes | <0.001 | 3.484 | 41 |
| Replication of Influenza A virus | <0.001 | 3.413 | 38 |
| Replication of virus | <0.001 | 3.314 | 64 |
| Leukocyte migration | <0.001 | 3.088 | 100 |
| Inflammatory response | <0.001 | 3.085 | 72 |
| Viral infection | <0.001 | 3.046 | 166 |
| Cytostasis | <0.001 | 2.913 | 30 |
| Replication of RNA virus | <0.001 | 2.782 | 56 |
| Cell movement | <0.001 | 2.766 | 173 |
| Migration of cells | <0.001 | 2.619 | 161 |
| Tyrosine phosphorylation of protein | <0.001 | 2.456 | 29 |
| Recruitment of cells | <0.001 | 2.451 | 34 |
| Recruitment of granulocytes | <0.001 | 2.405 | 26 |
| Polarization of leukocytes | <0.001 | 2.337 | 13 |
| Recruitment of leukocytes | <0.001 | 2.333 | 33 |
| Adhesion of immune cells | <0.001 | 2.271 | 40 |
| Recruitment of myeloid cells | <0.001 | 2.263 | 27 |
| Adhesion of blood cells | <0.001 | 2.250 | 41 |
| Cell viability | <0.001 | 2.240 | 112 |
| Orientation of macrophages | <0.001 | 2.200 | 6 |
| Attachment of cells | <0.001 | 2.166 | 18 |
| Disassembly of focal adhesions | <0.001 | 2.164 | 7 |
| Formation of membrane ruffles | <0.001 | 2.137 | 12 |
| Cell survival | <0.001 | 2.101 | 121 |
| Cell movement of neutrophils | <0.001 | 2.067 | 37 |
| Invasion of breast cancer cell lines | <0.001 | 2.064 | 25 |
| Orientation of cells | <0.001 | 2.028 | 19 |
| Decreased | <0.001 | ||
| Development of lymphoid organ | <0.001 | −3.241 | 30 |
| Development of lymphatic system component | <0.001 | −2.970 | 41 |
| Bacterial infection | <0.001 | −2.890 | 47 |
| Expansion of leukocytes | <0.001 | −2.753 | 25 |
| Expansion of lymphocytes | <0.001 | −2.635 | 21 |
| Development of lymph node | <0.001 | −2.608 | 14 |
| Morphology of germinal center | <0.001 | −2.415 | 11 |
| Morphology of lymph follicle | <0.001 | −2.415 | 15 |
| Expansion of blood cells | <0.001 | −2.384 | 26 |
| Encephalitis | <0.001 | −2.374 | 27 |
| Inflammation of organ | <0.001 | −2.362 | 97 |
| Quantity of neutrophils | 0.0011 | −2.208 | 23 |
| Development of thymocytes | <0.001 | −2.189 | 13 |
| Quantity of granulocytes | <0.001 | −2.133 | 36 |
| Organismal death | <0.001 | −2.074 | 196 |
An absolute z-score of ≥2 was designated as significant by the IPA software. The numbers of genes used to predict functional changes are indicated in the column with the heading “# of genes”.