Table 1.
Patient Demographics, Functional Assessment, and Neuropsychological Performance Profiles.
| Controls N=85 | svPPA N=83 | Case A | Case B | Case C | |
|---|---|---|---|---|---|
| Demographics | |||||
| Age | 75.1±10.0 | 63.9±7.5 | 56 | 61 | 69 |
| Years from first symptom | -- | 3.4±1.9 | 5 | 4 | 6 |
| Gender | 61.6(%Female) | 61.1 (%Female) | Female | Male | Female |
| Race | 93.0(%Caucasian) | 95.8 (%Caucasian) | Caucasian | Caucasian | Caucasian |
| Years of Education | 16.7±2.7 | 15.7±3.0 | 14 | 11 | 18 |
| Functional Assessment | |||||
| Functinoal Activities Questionnaire | 0.3±1.0 | 13±9.6 | 15 | 22 | 2 |
| Clinical Dementia Rating Box score | 0.3±0.7 | 4.9±3.9 | 4 | 5.5 | 2 |
| Clinical Dementia Rating Global | 0.1±0.2 | 0.9±0.66 | 0.5 | 1 | 0.5 |
| Tests | |||||
| MMSE (max=30) | 29.7±0.6 | 20.5±8.3 | 26 | 30 | 28 |
| Geriatric Depression Scale (max=30) | 3.3±3.1 | 9.1±7.2 | 1 | 3 | 2 |
| LANGUAGE | |||||
| Boston Naming Test (max=15) | 14.7±1.9 | 4.4±3.7 | 3 | 8 | 12 |
| Lexical Fluency (# D-words/minute) | 16.0±4.1 | 6.8±4.1 | 6 | 13 | 6 |
| Semantic Fluency (# animals/minute) | 23.8±4.6 | 7.1±5.4 | 8 | 13 | 14 |
| WRAT-4 Reading (max=70) | 65.4±3.1 | 50.1±15.6 | NA | NA | 64 |
| PPT- Picture (max=52) | 51.0±1.2 | 38.9±8.2 | 46 | NA | 50 |
| PPT-Word (max=52) | 51.6±1.0 | 37.8±10.3 | 45 | NA | NA |
| VERBAL MEMORY | |||||
| CVLT-SF Verbal Learning Trials 1-4 (max=36) | 31.3±2.4 | 13.7±7.5 | 8 | 27 | 24 |
| CVLT-SF 30″ Recall (max=9) | 8.2±0.8 | 2.4±2.4 | 3 | 8 | 6 |
| CVLT-SF 10′ Recall | 7.9±1.5 | 1.6±2.2 | 2 | 8 | 0 |
| CVLT-SF Recognition | 8.8±0.4 | 5.8±2.6 | 8 | 9 | 7 |
| VISUAL MEMORY | |||||
| Benson Figure 10′ Recall | 12.5±2.5 | 6.4±4.7 | 15 | 6 | 0 |
| VISUAL SPATIAL | |||||
| Benson Complex Figure Copy (max=17) | 15.6± 1.1 | 15.0±2.8 | 17 | 15 | 15 |
| VOSP Number Location (max=10) | 9.4±0.2 | 9.0±1.3 | 10 | 9 | 10 |
| EXECUTIVE FUNCTIONING | |||||
| Span of Digits Backward | 5.4±1.3 | 4.5±1.1 | 4 | 6 | 5 |
| Design Fluency (#/minute) | 11.5±2.9 | 7.3±4.5 | 7 | NA | 6 |
| Stroop Interference (# words/minute) | 54.8±11.3 | 32.9±15.3 | 36 | 40 | 47 |
| Calculations (max=5) | 4.8±0.6 | 4.3±1.2 | 4 | 4 | 4 |
85 controls and 83 patients with svPPA contributed valid test data and are included in the table. All test data represented as raw score. MMSE=Mini Mental Status Examination; WRAT-4 Reading = Wide Range Achievement Test 4, Reading Assessment; PPT-Picture= Pyramids and Palm Trees - Picture version; PPT-Word= Pyramids and Palm Trees - Word version; CVLT-SF= California Verbal Learning Test - Short Form; VOSP= Visual Object and Space Perception Battery. NA= data not available. Value displayed after ± indicates standard deviation.