Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 5;208(1):23–32. doi: 10.1083/jcb.201409108

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Daneshjou et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Relationship between VE-cadherin kinetics at AJs and stability of adhesive bonds. (A) Mathematical model describing VE-cadherin monomer–junction association and dissociation rate constants (j and k_a) followed by reversible trans-dimerization characterized by $k_{d}^{+}$ and $k_{d}^{-}$ . (B and C) COPASI-fitted experimental data from Fig. 2 (D and F) for basal (B) and after PA-Rac1 activation (C); dissociation rate constants are in minute⁻¹ ± SEM. (D) Estimated values for $k_{d}^{+}$ and $k_{d}^{-}$ described in A. (E and F) Time-lapse images of VE-cadherin−Dendra2 (VE-cad-Dendra2) W2,4A before and after photoconversion for basal (E) and PA-Rac1 activation (F) within the irradiation zone (circles). Time is in minutes and seconds. Bars, 10 µm. (G) Dissociation rate constant for wild type (0.18 ± 0.11 min⁻¹) and the W2,4A mutant without (0.54 ± 0.32 min⁻¹) and with PA-Rac1 activation (0.45 ± 0.19 min⁻¹); means ± SD, n = 9–15; *, P < 0.05. a.u., arbitrary unit.