Table 5.
IC50 values of antitumor drugs evaluated for colorectal carcinoma cell lines
| Cell line |
IC50 |
||||||||
| 5-FU (μg/mL) | Cisplatin (μg/mL) | Irinotecan (μmol/L) | Gemcitabine (μmol/L) | Paclitaxel1 | Trastuzumab2 | Erlotinib (μmol/L) | Nilotinib (μmol/L) | Rapamycin (μmol/L) | |
| HROC18 | 0.48 ± 0.28 | 1.58 ± 0.29 | 7.88 ± 2.26 | 3.35 ± 1.18 | Resistant | Resistant | 12.21 ± 5.4 | 7.55 ± 1.77 | 0.08 ± 0.04 |
| HROC32P | 0.15 ± 0.07 | 0.65 ± 0.40 | 0.15 ± 0.07 | 3.90 ± 2.16 | Resistant | Resistant | 1.40 ± 1.01 | 5.47 ± 3.13 | 0.14 ± 0.14 |
| HROC32X | 1.97 ± 1.95 | 1.30 ± 0.46 | 3.83 ± 1.40 | 5.90 ± 1.06 | Resistant | Resistant | 0.87 ± 0.15 | 5.5 ± 3.1 | 0.13 ± 0.06 |
1
Range 0.9 nmol/L: 60 mmol/L;
2
Range: 310 ng/mL: 20 μg/mL. Values are given as mean, resulting from at least three independent experiments each performed in triplicates. 5-FU: 5-Fluorouracil.