Table 1.
Correlation between CMT1A/HNPP age at onset (AOE) and I92V mutation within LITAF gene
| Patients | Parameters | Age at onset (years) | p value |
|---|---|---|---|
| HNPP > 10 + I92V | mean ± SD (n) | 18 ± 6 (16) | 0023 |
| median | 17.5 | ||
| min-max | 11–32 | ||
| HNPP > 10 | mean ± SD (n) | 37 ± 21 (7) | |
| median | 36 | ||
| min-max | 14–71 | ||
|
CMT1A > 10 +I92V |
mean ± SD (n) | 23 ± 10 (15) | 0005 |
| median | 20 | ||
| min-max | 11–47 | ||
| CMT1A > 10 | mean ± SD (n) | 36 ± 14 (30) | |
| median | 35.5 | ||
| min-max | 13–67 | ||
| CMT1A < 10 + I92V | mean ± SD (n) | 4.8 ± 3.2 (11) | 0.963 |
| median | 4 | ||
| min-max | 1.3–10 | ||
| CMT1A < 10 | mean ± SD (n) | 5.4 ± 4.4 (7) | |
| median | 3 | ||
| min-max | 1.5–10 |
HNPP > 10 + I92V patients with HNPP with AOE after 10 year of life with sequence variant Ile92Val in LITAF gene, HNPP > 10 patients with HNPP with AOE after 10 year of life without sequence variant Ile92Val in LITAF gene, CMT1A > 10 + I92V patients with CMT1A with AOE after 10 year of life with sequence variant Ile92Val in LITAF gene, CMT1A > 10 patients with CMT1A with AOE after 10 year of life without sequence variant Ile92Val in LITAF gene, CMT1A < 10 + I92V patients with CMT1A with AOE before 10 year of life with sequence variant Ile92Val in LITAF gene, CMT1A < 10 patients with CMT1A with AOE before 10 year of life with sequence variant Ile92Val in LITAF gene