Figure 3.

Macrophages are the predominant infiltrates in segmental fibrinoid necrosis of all causes. Infiltrating cell populations in glomeruli with segmental FN from biopsies with (A) pauci-immune necrotizing GN compared with (B) antiglomerular basement membrane GN (10 glomeruli from five patients) and (C) immune complex–mediated GN (nine glomeruli from six patients). The distribution and phenotypes are similar in each group, suggesting common effectors of glomerular injury in FN (data presented as means+SDs). Endo, endocapillary; Extra, extracapillary; @FN, at the site of fibrinoid necrosis; Peri, pericapsular; PMN, polymorphonuclear neutrophil.