Table 1.

Clinical and histologic data for patients with pauci-immune necrotizing GN and controls

PNGN (n=17)
Mean age, yr (range)	42.2 (3–74)
Sex	6 men, 11 women
Race/ethnicity	12 W, 3 L, 2 B
Proteinuria	16
Hematuria	17
Mean serum creatinine, mg/dl (range)	1.43 (0.5–6.6)
Mean eGFR, ml/min per 1.73 m2 (range)	81.3 (10.3–195.4)
ANCA-positive	14
Anti-MPO	8
Anti-PR3	6
ANCA negative	3
No. of glomeruli per biopsya	14 (5–27)
No. with segmental fibrinoid necrosis (range)	2 (1–5)
No. with cellular crescents (range)	2 (1–11)
No. with fibrous or fibrocellular crescents (range)	0.53 (0–3)
No. with normal appearance (range)	10 (3–25)
No. of globally sclerotic (range)	0.6 (0–3)
Interstitial inflammation scoreb	1.1±0.8
Tubulitis score	0.7±1
Interstitial fibrosis score	0.4±0.5
Tubular atrophy score	0.4±0.5
Acute tubular necrosis/injury	0
Arteriosclerosis score	0.8±0.9
Arteriolosclerosis score	0.6±0.8
Controls
Anti-GBM GN (n=5)
No. of glomeruli per biopsya	10 (5–14)
No. with segmental fibrinoid necrosis (range)	2 (1–4)
Immune complex GN (n=8)
SLE	4
IgAN	4
No. of glomeruli per biopsya	24.5 (10–45)
No. with segmental fibrinoid necrosis (range)	1.5 (1–4)
TBMN (n=5)
No. of glomeruli per biopsya	13 (8–22)

PNGN, pauci-immune necrotizing GN; MPO, myeloperoxidase; PR3, proteinase 3; GBM, glomerular basement membrane; SLE, systemic lupus erythematosus; IgAN, IgA nephropathy; TBMN, thin basement membrane nephropathy; W, white; L, Latino; B, black.

^aData given as mean (range) per biopsy.

^bMean score using the Banff schema (0–3)±SD.