Table 2.
Patient Characteristics | DOPPS Phase | |||
---|---|---|---|---|
Phase 1 | Phase 2 | Phase 3 | Phase 4 | |
Number of patients | 7615 | 7142 | 8559 | 12,339 |
Age, yr | 59.7±14.9 | 62.6±14.5 | 63.9±14.2 | 64.1±14.7 |
Men | 57.0 | 57.7 | 58.9 | 59.1 |
Black | 20.8 | 10.0 | 7.9 | 14.2 |
Body mass index, kg/m2 | 23.9±5.3 | 24.6±5.6 | 25.0±5.8 | 26.6±6.5 |
Time on dialysis, yra | 2.8 [1.2–5.8] | 2.9[1.3–5.6] | 2.5 [0.9–5.8] | 2.6 [0.9–5.5] |
Fistula | 52.6 | 62.5 | 65.7 | 62.5 |
Graft | 31.0 | 16.1 | 10.4 | 10.7 |
Catheter | 11.2 | 16.1 | 18.9 | 23.0 |
Diabetes | 29.9 | 31.3 | 35.4 | 41.8 |
Coronary arterial disease | 38.0 | 46.1 | 52.5 | 36.5 |
Congestive heart failure | 32.1 | 29.8 | 40.1 | 28.6 |
Cerebrovascular disease | 15.4 | 17.5 | 17.9 | 14.4 |
Peripheral arterial disease | 22.3 | 26.8 | 28.8 | 26.1 |
Hypertension | 76.3 | 78.8 | 81.2 | 81.5 |
Other cardiovascular disease | 33.4 | 35.6 | 37.2 | 26.5 |
Recurrent cellulitis | 7.8 | 8.2 | 8.5 | 9.9 |
Cancer (other than skin) | 8.1 | 11.7 | 13.0 | 12.2 |
Gastrointestinal bleeding | 7.2 | 6.0 | 5.4 | 4.4 |
Lung disease | 9.7 | 11.2 | 12.9 | 12.5 |
Neurologic disease | 8.3 | 11.4 | 11.7 | 10.2 |
Psychiatric disorder | 20.7 | 19.7 | 11.9 | 15.9 |
Hemoglobin, g/dl | 10.6±1.6 | 11.3±1.6 | 11.5±1.5 | 11.3±1.4 |
Serum albumin, g/dl | 3.8±0.5 | 3.7±0.5 | 3.8±0.5 | 3.7±0.5 |
Serum creatinine, mg/dl | 10.0±3.2 | 9.2±3.0 | 8.8±3.0 | 8.4±3.0 |
Serum calcium, mg/dl | 9.4±0.9 | 9.4±0.9 | 9.1±0.8 | 9.0±0.8 |
Serum phosphorus, mg/dl | 5.8±1.8 | 5.6±1.8 | 5.3±1.7 | 5.2±1.6 |
Parathyroid hormone, pg/mla | 149 [64–324] | 169 [78–333] | 203 [106–366] | 236 [131–401] |
Phosphate binder (any)b | 84.8 | 86.2 | 85.1 | 80.3 |
Phosphate binder (calcium-based) | NA | 67.5 | 57.3 | 47.5 |
Phosphate binder (noncalcium-based) | NA | 17.7 | 27.3 | 49.4 |
Untreated patients | 23.2 | 30.1 | 16.8 | 13.0 |
Data are shown as mean±SD or percentage. Dialysis Outcomes and Practice Patterns Study (DOPPS) phase 1: 1996–2001; phase 2: 2002–2004; phase 3: 2005–2008; phase 4: 2009–2011. NA, not applicable.
Median [interquartile range].
Includes calcium-based, noncalcium-based, or both. Type of phosphate binder (calcium-based or noncalcium-based) was not available in DOPPS phase 1.