Table 5.
Association of high parathyroid hormone levels with mortality
| Models | i.v. Method | Standard Cox Models | ||
|---|---|---|---|---|
| Hazard Ratio (95% Confidence Interval) | P Value | Hazard Ratio (95% Confidence Interval) | P Value | |
| Parathyroid hormone >300 pg/ml (versus ≤300) | ||||
| Adjustment Aa | 1.24 (0.99 to 1.55) | 0.06 | 1.12 (1.05 to 1.18) | <0.001 |
| Adjustment Bb | 1.11 (0.88 to 1.39) | 0.38 | 1.09 (1.03 to 1.15) | 0.004 |
| Parathyroid hormone >450 pg/ml (versus ≤450) | ||||
| Adjustment Aa | 1.44 (1.08 to 1.91) | 0.01 | 1.15 (1.08 to 1.23) | <0.001 |
| Adjustment Bb | 1.27 (0.95 to 1.69) | 0.10 | 1.10 (1.03 to 1.18) | 0.005 |
| Parathyroid hormone >600 pg/ml (versus ≤600) | ||||
| Adjustment Aa | 1.62 (1.12 to 2.35) | 0.02 | 1.22 (1.13 to 1.32) | <0.001 |
| Adjustment Bb | 1.44 (1.00 to 2.08) | 0.05 | 1.17 (1.08 to 1.27) | <0.001 |
a
Adjusted for patient age, sex, body mass index, time on dialysis, catheter use, comorbidities, albumin, hemoglobin, creatinine, facility percentage of patients with catheter use, percentage of patients having albumin <3.5 g/dl, and mean hemoglobin.
b
Also adjusted for additional covariates that may be intermediary in the pathway: patient calcium, phosphorus, phosphate binder, vitamin D analog, cinacalcet prescription, and facility percentage of patients having phosphorus >5.5 mg/dl.