Fig. 6.

Incidence of lung metastasis (per mm²) (a) and relative weighted tumor volume (b) in mice developing metastases. Bars represent mean ± 1 SEM. Amputation reduced the average incidence of metastasis when compared to treatment with saline alone or Zol and amputation; however, it did not result in a statistically significant difference (P = 0.154 and 0.125, adjusted threshold for significance P < 0.017, a). Despite an increase in average relative weighted tumor volume following Zol treatment in non-amputated mice (P = 0.122, adjusted threshold for significance P < 0.017, b), there were no statistically significant differences between treatment groups