. 2014 Aug 7;3(3):85–91. doi: 10.1016/j.amsu.2014.06.005

Table 6.

Definitions of grade III and grade II acute cholangitis from TG 13 [38].

Severe (grade III) acute cholangitis is defined as acute cholangitis that is associated with the onset of dysfunction in at least one of the following organs/systems:

1.
Cardiovascular system – hypotension requiring dopamine ≥ 5 μg/kg per min or any dose of norepinephrine
2.
Central nervous system – change in mental status or consciousness
3.
Respiratory system – PaO₂/FiO₂ ratio < 300
4.
Renal system – serum creatinine > 2 mg/dL
5.
Liver – PT-INR > 1.5
6.
Hematological system – platelets < 100,000/mm³

Moderate (grade II) acute cholangitis is associated with any two of the following:

1.
Abnormal white blood cell count (>12,000/mm³ or <4000/mm³)
2.
High fever (≥39 °C)
3.
Age (≥75 years old)
4.
Hyperbilirubinemia (total bilirubin ≥5 mg/dL)
5.
Hypoalbuminemia (<STD × 0.7)