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. 2004 Jun 7;101(24):8912–8917. doi: 10.1073/pnas.0401420101

Fig. 2.

Fig. 2.

MAOB is an ERRα target gene. (A) Quantitative RT-PCR of human MAOB mRNA expression in MDA-MB-231 cells overexpressing a retroviral vector, ERRα, or ERRαΔAF2. mRNA levels are expressed relative to the amount of cyclophilin mRNA. (B) VP16-ERRα and ERRγ transcriptional activation of the human MAOB promoter in transient transfections in HeLa cells. (C) Region of the human MAOB promoter containing the ERR response element (ERRE). The sequence of the MAOB ERRE, cloned as three copies into the TK-Luc reporter, is underlined. *, Nucleotides mutated from C to A in mutagenesis experiment. The TATA box is capitalized. (D) VP16-ERRα activation of wild-type and mutant forms of the human MAOB promoter in HeLa cells. (E) Transient transfection in HeLa cells with full-length ERRα and a luciferase reporter containing three copies of the MAOB ERR binding site (TK-MAOBx3-Luc) treated with various concentrations of XCT790 for 18 h. RLU, relative light units.