Table 2.
Changes in concentration, presented as fold values, for metabolites detected in the BBD community after 24 h exposure to 50 μg/L MC-LR as calculated from MetaboAnalyst 2.5 processed data [47]. Metabolites in the microcystin treated BBD community with the most robust differences (p ≤ 0.05 and fold change ≥1.5) from the control (t = 24, no exposure to microcystin) are bolded. Other potentially interesting metabolites with less robust changes (p ≤ 0.1 and/or fold change ≥1.25) are italicized.
| Metabolite | Fold Change | p Value |
|---|---|---|
| N,N-Dimethylglycine | 1.299 | 0.012 |
| Betaine | 1.281 | 0.051 |
| Thymine | 1.703 | 0.082 |
| l-Asparagine | 2.486 | 0.020 |
| l-Glutamine | 2.392 | 0.044 |
| l-Glutamate | 1.378 | 0.005 |
| Xanthine | 1.388 | 0.103 |
| l-Arginine | 1.588 | 0.039 |
| N-Carbamoyl-l-Aspartate | 1.349 | 0.086 |
| Deoxyuridine | 2.015 | 0.056 |
| Thiamine | 1.630 | 0.018 |
| S-Methyl-5’-Thioadenosine | 1.666 | 0.048 |
| N-Acetyl-Glucosamine-1/6-Phosphate | 1.423 | 0.019 |
| dUMP | 2.840 | 0.037 |
| Aminoimidazole Carboxamide Ribonucleotide | 1.471 | 0.001 |
| CDP-Choline | 1.426 | 0.078 |
| UDP-N-Acetyl-glucosamine | 1.376 | 0.034 |
| NAD+ | 1.435 | 0.008 |
| Cyclic bis-3,5-dimeric GMP | 1.802 | 0.065 |
| FAD | 1.367 | 0.042 |