Table 2. Overview of the principal ELVR studies*.
| Study | Study design | Patient population | Time point | ∆FEV1 | ∆6-MWT | ∆SGRQ | ∆TLVR | |
|---|---|---|---|---|---|---|---|---|
| Valves | Sciurba et al. 2010:„VENT“ (9) | Randomized. controlled | Treatment group (n = 214) | 6 months | 4.3% | 9.3m | −2.8pts | – |
| Herth et al. 2012: „Euro-VENT” (10) | Randomized. controlled | Treatment group (n = 111) | 6 months | 7±20% | 15±91m | −5±14pts | – | |
| Subgroup with complete fissure. complete lobar occlusion (n = 20) | 26±24% | 22±38% | −10±15pts | 80% | ||||
| Herth et al. 2013: „Chartis-Study” (20) | Prospective. noncontrolled | CV negative (n = 51) | 1 month | 16±22% | 24±57m | −10±13pts | 56% | |
| CV positive (n = 29) | 1±15% | 10±57m | −5±15pts | 6% | ||||
| Eberhardt et al. 2012:„Complete unilateral vs. partial bilateral“ (23) | Prospective. randomized. noncontrolled | Complete unilateral occlusion (n = 11) | 3 months | 21±11% | 49±53m | −12±11pts | – | |
| Partial bilateral occlusion (n = 11) | −3±15% | −52±81 m | 2±9pts | – | ||||
| Ninane et al. 2012: „Multicenter European study“ (11) | Randomized. controlled | Partial occlusion (n = 37) | 3 months | −90mL | 7m | −4pts | 7% | |
| Coils | Slebos et al. 2012:„Bronchoscopic lung volume reduction coil treatment“ (26) | Prospective. noncontrolled | Treatment group (n = 16) | 6 months | 15±17% | 84±73m | −15±12pts | – |
| Shah et al. 2013:„RESET“ (12) | Randomized. controlled | Treatment group (n = 23) | 3 months | 14% | 52m | −8pts | – | |
| BTVA | Snell et al. 2012: „Bronchoscopic thermal vapor ablation therapy“ (29) | Prospective. noncontrolled | Treatment group (n = 44) | 6 months | 17% | 47m | −14pts | 48% |
*The inclusion and exclusion criteria of the individual studies differ only slightly. Alongside lung function parameters. exercise tolerance and distribution of emphysema are relevant for study inclusion. With regard to lung function. the preconditions for inclusion were as follows: FEV1 <45% and RV >150% (9–11, 29 ); FEV1 < 50% (20); FEV1 <40% and RV >150% (23); FEV1 <45% and TLC >100% (12,26 ). ELVR. endoscopic lung volume reduction; FEV1. forced expiratory volume in 1 s; 6-MWT. 6-minute walking test; SGRQ. St. George’s Respiratory Questionnaire; TLVR. target lobe volume reduction; CV. collateral ventilation; RV. residual volume; TLC. total lung capacity