Fig. 3.

Mice deficient in Rbm38 are prone to spontaneous tumors. (A) Spontaneous tumor spectrum in WT (n = 17) and Rbm38^−/− (n = 23) mice (P = 0.023 by Fisher’s exact test). (B) H&E-stained sections of hemangiosarcoma in the liver of an Rbm38^−/− mouse at 20× (Left) and 200× (Right). (C) H&E-stained sections of hepatoma in the liver of an Rbm38^−/− mouse at 20× (Left) and 200× (Right). (D) The level of IL17D, Tnfsf15, and TLR7 transcripts was determined from WT and Rbm38^−/− MEFs by RT-PCR analysis.