Fig. 4.

Loss of Rbm38 sensitizes mice to IR-induced lethality in a p53-dependent manner. (A) WT and Rbm38^−/− mice were exposed to 4 gray of whole body γ-irradiation. Four hours postirradiation, lysates from spleen and thymus were collected, and the level of Rbm38, p53, phospho-γ-H2AX, and actin was determined. (B) Kaplan–Meier survival curves of WT (n = 29), Rbm38^−/− (n = 38), p53^−/−(n = 10), and Rbm38^−/−; p53^−/− (n = 14) mice after 8 gray of whole-body γ-irradiation.