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Loss of Rbm38 significantly reduces the tumor penetrance in p53-heterozygous mice. (A) The level of Rbm38, p53, and actin was determined in p53+/− and Rbm38−/−; p53+/− MEFs. (B) Kaplan–Meyer survival curves of p53+/− (n = 24) and Rbm38−/−; p53+/− (n = 21) mice (P = 0.371 by log-rank test). (C) Comparison of tumor-free mice between a cohort of p53+/− and Rbm38−/−; p53+/− mice.
