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. 2014 Dec 15;5:5778. doi: 10.1038/ncomms6778

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(a) On yeast-rich (or regular) food, SE0_PG neurons innervate the PG and activate serotonin signalling in the PG. Serotonin signalling accelerates ecdysteroid biosynthesis by upregulating the expressions of ecdysteroidogenic genes in the late third instar stage. This leads to the larva-to-pupa transition (pupariation) at 96–120 hAH. (b) On yeast-poor food, SE0_PG neurons barely project to the PG so that serotonin signalling is not activated. In this case, the timing of pupariation is delayed to 120–168 hAH.