Table 3.
Single nucleotide polymorphism genetic models and analyses of the association between SNPs and acute mountain sickness (AMS) adjusted for age and smoking status.
| SNP Number | Model | Genotype | AMS+ [n (%)] | AMS− [n (%)] | OR (95% CI) | p-Value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs12406290 | Codominant | AA | 65 (34.6) | 42 (22.7) | 1.00 | – | – | – |
| AG | 86 (45.7) | 96 (51.9) | 1.74 (1.07–2.84) | – | – | – | ||
| GG | 37 (19.7) | 47 (25.4) | 1.91 (1.06–3.41) | 0.04 | 522.9 | 554.3 | ||
| Dominant | AA | 65 (34.6) | 42 (22.7) | 1.00 | – | – | – | |
| AG + GG | 123 (65.4) | 143 (77.3) | 1.79 (1.13–2.84) | 0.012 * | 521 | 548.5 | ||
| Recessive | AA + AG | 151 (80.3) | 138 (74.6) | 1.00 | – | – | – | |
| GG | 37 (19.7) | 47 (25.4) | 1.34 (0.82–2.19) | 0.24 | 526 | 553.5 | ||
| Overdominant | AA + GG | 102 (54.3) | 89 (48.1) | 1.00 | – | – | – | |
| AG | 86 (45.7) | 96 (51.9) | 1.31 (0.87–1.97) | 0.19 | 525.7 | 553.1 | ||
| Log-additive | – | – | – | 1.40 (1.05–1.87) | 0.022 | 522.1 | 549.6 | |
| rs2153364 | Codominant | AA | 63 (33.5) | 38 (21.1) | 1.00 | – | – | – |
| AG | 88 (46.8) | 95 (52.8) | 1.85 (1.12–3.05) | – | – | – | ||
| GG | 37 (19.7) | 47 (26.1) | 2.14 (1.18–3.88) | 0.019 | 514.4 | 545.6 | ||
| Dominant | AA | 63 (33.5) | 38 (21.1) | 1.00 | – | – | – | |
| AG + GG | 125 (66.5) | 142 (78.9) | 1.94 (1.20–3.11) | 0.0057 * | 512.7 | 540 | ||
| Recessive | AA + AG | 151 (80.3) | 133 (73.9) | 1.00 | – | – | – | |
| GG | 37 (19.7) | 47 (26.1) | 1.43 (0.88–2.34) | 0.15 | 518.2 | 545.6 | ||
| Overdominant | AA + GG | 100 (53.2) | 85 (47.2) | 1.00 | – | – | – | |
| AG | 88 (46.8) | 95 (52.8) | 1.30 (0.86–1.96) | 0.22 | 518.8 | 546.1 | ||
| Log-additive | – | – | – | 1.47 (1.10–1.98) | 0.0095 | 513.6 | 540.9 |
Numbers and frequencies of AMS+ or AMS− in each genotype were shown. AIC: Akaike’s information criterion; BIC: Bayesian information criterion. * Best-fit model p-value.