Table 4.
Haplotype frequencies and the association with AMS risk adjusted for age and smoking status.
| Gene | Blocks | Haplotype a | Frequency of AMS− (%) | Frequency of AMS+ (%) | p-Value | Odds Ratio 95% CI |
|---|---|---|---|---|---|---|
| EGLN1 | Global haplotype association test p = 0.004 c | |||||
| Block 1 | AA | 60.9 | 54.75 | – | 1.00 b | |
| GG | 39.1 | 43.63 | 0.12 | 1.25 (0.94–1.66) | ||
| Global haplotype association test p = 0.036 c | ||||||
| Block 2 | AA | 56.83 | 48.92 | – | 1.00 b | |
| GG | 42.1 | 50.79 | 0.029 * | 1.38 (1.04–1.85) | ||
| HIF-1AN | Global haplotype association test p = 0.7 c | |||||
| Block 3 | CTTGG | 90.26 | 90.63 | – | 1.00 b | |
| TCACA | 9.74 | 9.37 | 0.7 | 0.91 (0.57–1.46) | ||
Frequency of each haplotype block was shown in percentage. a, Haplotypes with frequency ≥0.05 were shown; b, Reference haplotype; c, A global test was performed for the null hypothesis such that no haplotype was associated with the risk of AMS. The analyses were adjusted by age and smoking status. * p < 0.05; Block 1 consisted of rs2009873-rs2739513; Block 2 consisted of rs12406290-rs2153364; Block 3 consisted of rs1054399, rs11190613, rs11292, rs11816840 and rs3750633.