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. 2004 Jun 7;101(24):9039–9044. doi: 10.1073/pnas.0403093101

Fig. 1.

Fig. 1.

Genome-wide screening to find GCR mutators. (A) A library composed of strains carrying the GCR assay system, a pif1Δ mutation, and 1 of 4,644 gene deletion mutations was generated. (B) Secondary screening identified three types of GCR mutator mutations (see Table 1). (C) Screen results for CAN and GCR (CAN-5FOA) mutator screens. Primary screen is shown in Left, and secondary screen is shown in Right. In the CAN mutator assay, only one plate was used for the primary screen. Putative GCR mutators were selected only when two independent FC plates generated more than five colonies.