Table 5.
Association between CHI3L1 genotypes and YKL-40 levels
| CHI3L1 Genotypes | Health Examination Subjects | PAD | |||||
|---|---|---|---|---|---|---|---|
| YKL-40 Level Means ± SD (N) | p Value | Adjusted p | YKL-40 Level Means ± SD (N) | * p Value | Adjusted p | ||
| rs10399931 | CC | 104.77 ± 110.27 (232) | 3.12 × 10−6 | 1.87 × 10−5 | 548.74 ± 356.70 (30) | 0.011 | 0.066 |
| CT | 82.79 ± 65.46 (267) | 346.76 ± 197.28 (40) | |||||
| TT | 74.98 ± 88.40 (79) | 290.43 ± 232.65 (16) | |||||
| CC | 104.77 ± 110.27 (232) | 6 × 10−10 | 3.6 × 10−9 | 548.74 ± 356.70 (30) | 0.001 | 0.006 | |
| CT + TT | 81.01 ± 71.29 (346) | 330.67 ± 207.41 (56) | |||||
| rs10399805 | AA | 102.67 ± 114.85 (42) | 0.328 | 1.00 | 568.36 ± 417.22 (10) | 0.072 | 0.432 |
| AG | 87.79 ± 71.23 (230) | 452.92 ± 282.13 (32) | |||||
| GG | 93.14 ± 98.01 (308) | 336.42 ± 236.43 (44) | |||||
| AA + AG | 90.09 ± 79.44 (272) | 0.362 | 1.00 | 480.40 ± 317.60 (42) | 0.074 | 0.444 | |
| GG | 93.14 ± 98.01 (308) | 336.42 ± 236.43 (44) | |||||
| rs4950928 | CC | 100.99 ± 99.59 (404) | 8.36 × 10−7 | 5.02 × 10−6 | 467.63 ± 302.62 (61) | 1.94 × 10−4 | 1.16 × 10−3 |
| CG | 71.64 ± 56.42 (154) | 283.39 ± 174.75 (21) | |||||
| GG | 59.65 ± 53.66 (21) | 125.73 ± 77.11 (4) | |||||
| CC | 100.99 ± 99.59 (404) | 2.29 × 10−10 | 1.37 × 10−9 | 467.63 ± 302.62 (61) | 6.61 × 10−6 | 3.97 × 10−5 | |
| CG + GG | 70.20 ± 56.09 (175) | 258.17 ± 172.25 (25) | |||||
p Value, adjusted for age, sex, BMI, current smoker, use of antihypertensive, antidiabetic and lipid lowering drugs; * p value, adjusted for age, sex, BMI, current smoker, antihypertensive and lipid lowering drugs; Adjusted p values were computed by utilizing the Bonferroni method.