Table 6.
Association of CHI3L1 locus haplotypes with YKL-40 level.
| Haplotypes | Health Examination Subjects | PAD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP1 | SNP2 | SNP3 | Frequency | Estimate | p Value | Adjusted p | Frequency | Estimate | * p Value | Adjusted p | |
| H1 | C | G | C | 35.22% | 0.172 | 1.78 × 10−8 | 7.12 × 10−8 | 27.91% | 0.248 | 0.037 | 0.148 |
| H2 | C | A | C | 26.93% | 0.049 | 0.136 | 0.544 | 30.23% | 0.179 | 0.086 | 0.344 |
| H3 | T | G | C | 21.04% | −0.067 | 0.066 | 0.264 | 25.00% | 0.037 | 0.343 | 1.000 |
| H4 | T | G | G | 15.30% | −0.252 | 1.72 × 10−10 | 6.88 × 10−8 | 16.86% | −0.560 | 1.06 × 10−6 | 4.24 × 10−6 |
SNP1: rs10399931, SNP2: rs10399805, SNP3: rs4950928. Coefficients and p values were estimated based on haplotype trend regression analysis implemented in the HelixTree program. The selected haplotype compared to all unselected haplotypes; p value, adjusted for age, sex, BMI, current smoker, use of antihypertensive, antidiabetic and lipid lowering drugs; * p Value, adjusted for age, sex, BMI, current smoker, antihypertensive and lipid lowering drugs; Adjusted p values were computed by utilizing the Bonferroni method.