Table 1. Kinetics of CTL activity and IFN-γ production by CD8 splenocytes from ECTV-infected mice.

	C57BL/6			BALB/c
Days p.i.	Cytolysis*	IFN-γ production†	IFN-γ-producing cells,‡n	Cytolysis	IFN-γ production	IFN-γ-producing cells, n
1	0	<3.0	0	0	<3.0	0
2	0	<3.0	15 ± 2	0	<3.0	0
3	0	<3.0	20 ± 2	0	<3.0	3 ± 1
4	0	<3.0	20 ± 2	0	<3.0	5 ± 1
5	2.1 ± 0.2	<3.0	22 ± 3	0	<3.0	4 ± 1
6	7.2 ± 1.1	22.7 ± 2.4	32 ± 2	5.8 ± 0.8	<3.0	6 ± 2
7	20.9 ± 1.3	35.9 ± 2.8	25 ± 3	13.1 ± 1.9	<3.0	2 ± 1
8	58.0 ± 3.8	45.4 ± 5.7	16 ± 2	ND	ND	ND
12	24.1 ± 2.3	25.1 ± 3.3	11 ± 2	ND	ND	ND

ND, not done.

^*CTL responses in the spleen. Data shown are mean ± SEM of percent of specific lysis of syngeneic targets from five mice per group at effector-to-target-cell ratio of 20:1.

^†IFN-γ production by splenocytes depleted of CD4 cells. Data shown are mean ± SEM units/ml from triplicate cultures for each group of five mice.

^‡Number of IFN-γ-producing cells per mm² in the spleens of infected mice as determined by immunohistochemistry (Fig. 4).