Table 5.
Stratified analysis of rs3790843 and rs3790844 polymorphism among GC patients.
| rs3790843 | rs3790844 | |||||||
|---|---|---|---|---|---|---|---|---|
| TT | TC/CC | HR (95% CI) e | p | GG | GA/AA | HR (95% CI) e | p | |
| Age (years) | ||||||||
| ≤60 | 88/192 | 108/237 | 0.977 (0.737–1.294) | 0.869 | 90/182 | 107/249 | 0.806 (0.609–1.067) | 0.132 |
| >60 | 108/222 | 115/256 | 0.873 (0.672–1.136) | 0.313 | 107/217 | 116/264 | 0.837 (0.644–1.089) | 0.185 |
| Sex | ||||||||
| Male | 144/321 | 175/375 | 1.044 (0.838–1.302) | 0.700 | 149/311 | 172/391 | 0.877 (0.705–1.093) | 0.243 |
| Female | 52/93 | 48/118 | 0.619 (0.417–0.916) | 0.017 | 48/88 | 51/122 | 0.660 (0.445–0.981) | 0.040 |
| Location | ||||||||
| Non–CardiaCancer | 133/279 | 148/320 | 0.948 (0.750–1.198) | 0.652 | 133/264 | 148/338 | 0.810 (0.641–1.024) | 0.077 |
| CardiaCancer | 63/135 | 75/173 | 0.861 (0.615–1.204) | 0.381 | 64/135 | 75/175 | 0.840 (0.601–1.174) | 0.308 |
| Tumor Size | ||||||||
| ≤5 cm | 108/261 | 127/302 | 1.044 (0.807–1.349) | 0.745 | 106/243 | 132/324 | 0.927 (0.718–1.197) | 0.559 |
| >5 cm | 88/153 | 96/191 | 0.747 (0.558–0.999) | 0.049 | 91/156 | 91/189 | 0.693 (0.517–0.928) | 0.014 |
| Lymph Node Metastasis a | ||||||||
| N0 | 64/180 | 60/182 | 0.947 (0.666–1.347) | 0.763 | 63/168 | 63/197 | 0.865 (0.610–1.226) | 0.414 |
| N1/N2/N3 | 132/234 | 163/311 | 0.829 (0.659–1.043) | 0.109 | 134/231 | 160/316 | 0.744 (0.591–0.937) | 0.012 |
| Distant Metastasis | ||||||||
| M0 | 188/398 | 200/456 | 0.886 (0.726–1.081) | 0.232 | 188/382 | 202/478 | 0.793 (0.650–0.968) | 0.022 |
| M1 | 8/16 | 23/37 | 1.340 (0.599–2.998) | 0.476 | 7/9 | 21/35 | 1.189 (0.544–2.599) | 0.664 |
| Histological Types b | ||||||||
| Intestinal | 71/168 | 80/187 | 1.041 (0.756–1.434) | 0.805 | 69/156 | 84/205 | 0.952 (0.692–1.309) | 0.762 |
| Diffuse | 108/207 | 127/270 | 0.826 (0.639–1.068) | 0.145 | 111/206 | 123/270 | 0.735 (0.568–0.950) | 0.019 |
| Differentiation b | ||||||||
| Well to Moderate | 57/137 | 67/155 | 1.099 (0.772–1.565) | 0.601 | 56/127 | 69/170 | 0.962 (0.676–1.368) | 0.828 |
| Poorly | 104/208 | 126/267 | 0.882 (0.680–1.144) | 0.344 | 105/205 | 125/270 | 0.822 (0.634–1.067) | 0.140 |
| Others c | 18/30 | 14/35 | 0.522 (0.259–1.056) | 0.07 | 19/30 | 13/35 | 0.397 (0.195–0.808) | 0.011 |
| Lauren b | ||||||||
| 1 | 69/182 | 78/199 | 1.049 (0.759–1.451) | 0.771 | 69/169 | 80/218 | 0.899 (0.652–1.241) | 0.655 |
| 2 | 125/229 | 144/293 | 0.824 (0.648–1.047) | 0.113 | 126/227 | 142/294 | 0.763 (0.600–0.970) | 0.027 |
| Chemotherapy | ||||||||
| No | 132/275 | 151/333 | 0.908 (0.719–1.147) | 0.416 | 136/266 | 149/348 | 0.767 (0.608–0.968) | 0.025 |
| Yes | 64/139 | 72/160 | 0.957 (0.683–1.340) | 0.799 | 61/133 | 74/165 | 0.953 (0.679–1.338) | 0.783 |
| Depth of Invasion d | ||||||||
| T1 | 25/86 | 34/93 | 1.297 (0.774–2.173) | 0.324 | 24/76 | 33/101 | 1.051 (0.621–1.779) | 0.852 |
| T2 | 31/60 | 24/69 | 0.669 (0.393–1.141) | 0.140 | 31/59 | 25/71 | 0.648 (0.382–1.099) | 0.107 |
| T3 | 1/3 | 2/3 | 1.405 (0.125–15.838) | 0.782 | 1/2 | 2/4 | 0.809 (0.071–9.157) | 0.864 |
| T4 | 134/257 | 159/320 | 0.880 (0.699–1.108) | 0.276 | 135/254 | 157/326 | 0.809 (0.642–1.019) | 0.072 |
| TNM Stage | ||||||||
| I | 40/120 | 39/118 | 0.992 (0.638–1.542) | 0.972 | 40/111 | 40/128 | 0.862 (0.556–1.336) | 0.506 |
| II | 38/83 | 38/111 | 0.743 (0.474–1.166) | 0.196 | 37/78 | 41/119 | 0.711 (0.456–1.109) | 0.132 |
| III | 111/198 | 135/248 | 0.861 (0.670–1.108) | 0.245 | 113/198 | 132/250 | 0.800 (0.622–1.029) | 0.082 |
| IV | 4/10 | 8/13 | 1.855 (0.557–6.171) | 0.314 | 4/9 | 7/13 | 1.257 (0.368–4.302) | 0.715 |
HR, hazard ratio; CI, confidence interval; AJCC, American Joint Commission on Cancer; TNM, Tumor, Node and Metastasis. a: Lymph nodes were staged according to tumor node metastasis classification of the 7th edition of AJCC in which the number of lymph nodes with a metastasis of 1–2, 3–6, and ≥7 were classified as N1, N2, and N3, respectively; b: Partial data were not available, and statistics were based on available data; c: Others: mucinous carcinoma and Signet-ring cell carcinoma; d: Invaded depth of tumor was classified according to the criteria of AJCC 7th; e: Adjusted by age and sex.