Table 1. Levels of mRNA and protein expression inhibition of different viral genes in cells treated with liposome complexes in the presence of TK1 alone or plus R1 or R2 as compared with levels in cells treated with liposome complexes in the absence of EGSs (BCBL-1).
| KSHV gene | Viral gene class | BCBL-1, % | R1, % | R2, % | TK1, % |
|---|---|---|---|---|---|
| Rta mRNA | Immediate-early | 0 | 93 ± 6 | 9 | 1 |
| Polyadenylated nuclear RNA | Early | 0 | 83 ± 4 | 3 | 1 |
| vIL-6 mRNA | Early/late | 0 | 85 ± 5 | 2 | 0 |
| Rta protein | Immediate-early | 0 | 90 ± 5 | 5 | 2 |
| ORF59 protein | Early | 0 | 8 ± 5 | 3 | 1 |
| ORF65 mRNA | Late | 0 | 80 ± 5 | 2 | 2 |
| K8.1 protein | Late | 0 | 80 ± 6 | 3 | 1 |
The values shown are the means from triplicate experiments. SD values <5% are not shown.