Table 2.
Antimicrobial activity of compounds 6a–l (200 μg/8 mm disc), the broad spectrum antibacterial drugs Gentamicin (100 μg/8 mm disc), Ampicillin (100 μg/8 mm disc) and the antifungal drug Clotrimazole (100 μg/8 mm disc) against Staphylococcus aureus IFO 3060 (SA), Bacillus subtilis IFO 3007 (BS), Micrococcus luteus IFO 3232 (ML), Escherichia coli IFO 3301 (EC), Pseudomonas aeuroginosa IFO 3448 (PA), and Candida albicans IFO 0583 (CA).
| Comp. No. | Clog p | Diameter of Growth Inhibition Zone (mm) a | |||||
|---|---|---|---|---|---|---|---|
| SA | BS | ML | EC | PA | CA | ||
| 6a | 3.96 | – | – | – | – | – | – |
| 6b | 5.51 | – | – | – | – | – | – |
| 6c | 5.67 | – | – | – | – | – | – |
| 6d | 5.69 | 15 | 17 | 11 | – | – | – |
| 6e | 6.59 | 21 (8) b | 20 (4) b | 17 | 14 | – | – |
| 6f | 4.72 | 15 | 18 (8) b | 11 | – | – | – |
| 6g | 4.21 | 11 | 13 | – | – | – | – |
| 6h | 5.76 | – | 12 | – | – | – | – |
| 6i | 5.92 | 14 | 16 | 12 | – | – | – |
| 6j | 5.82 | 19 (8) b | 18 (16) b | 18 (16) b | – | – | – |
| 6k | 6.84 | 28 (0.5) b | 30 (0.5) b | 19 (8) b | 18 (16) b | 12 | – |
| 6l | 4.97 | 17 | 19 (8) b | 10 | – | – | – |
| Gentamicin | 26 (2) b | 25 (2) b | 18 (2) b | 20 (0.5) b | 19 (1) b | NT | |
| Ampicillin | 23 (2) b | 21 (0.5) b | 19 (2) b | 17 (2) b | 16 (2) b | NT | |
| Clotrimazole | NT | NT | NT | NT | NT | 21 (2) b | |
a (–): Inactive (inhibition zone < 10 mm); NT: Not tested. b The figures shown in parentheses represent the minimal inhibitory concentration (MIC) values (μg/mL).