Table 3.

The catalytic (k_cat) and the apparent second-order rate (k_cat/K_m) constants of reduction of BFXs and NACs by NAD(P)H:quinone oxidoreductase (NQO1), pH 7.0, 25 °C. All kinetic measurements were performed at fixed concentration of NADPH (150 µM).

No.	Compound	kcat (s−1)	kcat/Km (M−1·s−1)
	Benzofuroxans
1.	Benzofuroxan	11.0 ± 1.5	8.4 ± 0.3 × 104
2.	5-Methylbenzofuroxan	2.4 ± 0.4	1.4 ± 0.1 × 104
3.	5-Dimethylbenzofuroxan	1.8 ± 0.2	4.7 ± 1.1 × 103
4.	5-Chlorobenzofuroxan	5.6 ± 0.6	6.2 ± 0.5 × 104
5.	5,6-Dichlorobenzofuroxan	6.9 ± 0.1	1.3 ± 0.1 × 105
6.	5-Methoxybenzofuroxan	4.4 ± 0.1	2.5 ± 0.4 × 104
7.	5,6-Dimethoxybenzofuroxan	1.1 ± 0.1	1.4 ± 0.3 × 104
8.	5-Trifluorobenzofuroxan	7.6 ± 0.9	2.5 ± 0.4 × 105
9.	5,6-Methylendioxybenzofuroxan	1.2 ± 0.4	4.6 ± 0.9 × 103
10.	5,6-Ethylendioxybenzofuroxan	0.7 ± 0.1	8.1 ± 1.7 × 103
11.	Benzodifuroxan	2.3 ± 0.4	1.6 ± 0.3 × 104
12.	Benzotrifuroxan	2.6 ± 0.3	3.8 ± 0.4 × 104
	Nitrobenzenes
13.	Nitrobenzene	<0.1	2.4 ± 0.2 × 101
14.	1,2-Dinitrobenzene	<0.1	6.6 ± 0.7 × 102
15.	1,3-Dinitrobenzene	0.3	7.4 ± 0.7 × 102
16.	1,4-Dinitrobenzene	0.6 ± 0.1	2.4 ± 0.1 × 103
17.	2,4,6-Trinitrotoluene	1.0	6.7 ± 0.7 × 102