Table 2.
Advantages and disadvantages of hMSCs, hESCs, and hiPSCs for differentiation into β-cells.
| Advantage and Disadvantage of Clinical Conditions | hMSCs | hESCs | hiPSCs |
|---|---|---|---|
| Ethical concern | no | yes | no |
| Xeno-free, feeder free culture | easy | difficult | difficult |
| Preparation of pluripotent (multipotent) stem cells | easy | relatively difficult | relatively difficult |
| Long-term expansion | difficult | easy | easy |
| Differentiation ability into β-cells | low | high | high |
| Tumor generation possibility | no | yes | yes |
| Mass production for clinical usage | no | yes | yes |