Table 2.
Effect of poly(dl-lactide-co-glycolide) (PLGA), the theoretical drug loading (TDL), poly(vinyl alcohol) (PVA) and power of sonication (Power Son.) on the on the nanoparticle’s (NPs) size and polydispersity (PDI). (Numbers in bold are discussed below).
| PLGA (%) | TDL (%) | PVA (%) | Power Son. (%) | PPH | CPZ-HCl | ||
|---|---|---|---|---|---|---|---|
| NPs (nm) | PDI | NPs Size (nm) | PDI | ||||
| 0.8 | 20 | 0.5 | 30 | 340.5 ± 17.8 | 0.112 ± 0.016 | 374.3 ± 10.1 | 0.149 ± 0.003 |
| 1.3 | 20 | 0.5 | 30 | 382.5 ± 36.5 | 0.119 ± 0.022 | 374.3 ± 10.1 | 0.149 ± 0.003 |
| 1.6 | 20 | 0.5 | 30 | 376.6 ± 28.6 | 0.107 ± 0.034 | 426.0 ± 19.4 | 0.123 ± 0.037 |
| 1.3 | 10 | 0.5 | 30 | 367.2 ± 22.7 | 0.138 ± 0.013 | 382.4 ± 10.2 | 0.178 ± 0.030 |
| 1.3 | 30 | 0.5 | 30 | 397.1 ± 31.1 | 0.149 ± 0.048 | 397.9 ± 28.8 | 0.098 ± 0.016 |
| 1.3 | 20 | 0.3 | 30 | – | – | 476.7 ± 11.2 | 0.243 ± 0.032 |
| 1.3 | 20 | 0.7 | 30 | 325.5 ± 32.4 | 0.105 ± 0.020 | 395.2 ± 24.4 | 0.150 ± 0.016 |
| 1.3 | 20 | 0.5 | 50 | 363.0 ± 30.9 | 0.109 ± 0.010 | 403.5 ± 12.2 | 0.148 ± 0.013 |
| 1.3 | 20 | 0.5 | 70 | 419.1 ± 23.4 | 0.158 ± 0.004 | 443.0 ± 11.1 | 0.183 ± 0.030 |