Figure 7. p53-regulated lncRNAs constitute a tumour-suppressor signature in colorectal cancer.
(a) Relative expression level of p53-regulated lncRNAs in a cohort of 35 tumour samples compared with the normal peripheral tissue. The highlighted candidates are significantly downregulated in the tumours (P<0.01). (b) ROC analysis of the sensitivity and specificity for the training cohort for the seven significant p53-regulated lncRNAs. Multivariate ROC analysis for the five p53-regulated lncRNAs with AUC values >0.7. (c) Clustering of the expression levels of the p53-regulated lncRNAs with AUC values >0.7. Rows represent lncRNAs and columns represent patients.