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. 2014 Jul 30;87(1):74–84. doi: 10.1038/ki.2014.271

Figure 4.

Figure 4

Nlrp3 (nucleotide-binding domain and leucine-rich repeat pyrin 3 domain) or caspase-1-deficiency ameliorates diabetic nephropathy (DN). Albuminuria and fractional mesangial area (FMA) are significantly reduced in Nlrp3−/− (a) or caspase-1−/− (b) diabetic mice in comparison with wild-type diabetic mice (WT DM). Mean value±s.e.m. Number of mice (a, b) in each group is shown in parentheses in a; representative periodic acid Schiff-stained glomeruli; scale bar (a, b)=20 μm; *P<0.05, **P<0.01.