Table 2.
Odds ratios (ORs) for BMI and colon cancer by age, decade, and gendera
| Total population |
Males |
Females |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | OR (95% CI) | P | P * | Cases/controls | OR (95% CI) | P | P * | Cases/controls | OR (95% CI) | P | P * | |
| BMI in the “recruitment period”b | ||||||||||||
| Normalc | 109/159 | 1.00 (Referent) | – | – | 45/45 | 1.00 (Referent) | – | – | 64/114 | 1.00 (Referent) | – | – |
| Overweight | 145/170 | 1.08 (0.73–1.60) | 0.70 | – | 78/77 | 1.13 (0.62–2.07) | 0.69 | – | 67/93 | 0.97 (0.57–1.67) | 0.92 | – |
| Obese | 166/143 | 1.54 (1.03–2.31) | 0.03 | 0.03 | 85/60 | 1.63 (0.87–3.04) | 0.13 | 0.12 | 81/83 | 1.51 (0.86–2.64) | 0.15 | 0.16 |
| BMI in the 50s | ||||||||||||
| Normalc | 196/278 | 1.00 (Referent) | – | – | 84/91 | 1.00 (Referent) | – | – | 112/187 | 1.00 (Referent) | – | – |
| Overweight | 134/113 | 1.21 (0.84–1.74) | 0.31 | – | 77/53 | 1.22 (0.70–2.13) | 0.49 | – | 57/60 | 1.15 (0.69–1.92) | 0.60 | – |
| Obese | 90/81 | 1.31 (0.86–2.01) | 0.21 | 0.18 | 47/38 | 1.16 (0.61–2.21) | 0.65 | 0.59 | 43/43 | 1.48 (0.81–2.72) | 0.21 | 0.21 |
| BMI in the 40s | ||||||||||||
| Normalc | 254/272 | 1.00 (Referent) | – | – | 105/78 | 1.00 (Referent) | – | – | 149/194 | 1.00 (Referent) | – | – |
| Overweight | 104/123 | 0.89 (0.60–1.30) | 0.54 | – | 68/66 | 0.86 (0.51–1.46) | 0.59 | – | 36/57 | 0.86 (0.47–1.58) | 0.63 | – |
| Obese | 62/77 | 0.85 (0.52–1.39) | 0.52 | 0.44 | 35/38 | 0.71 (0.36–1.42) | 0.33 | 0.32 | 27/39 | 1.04 (0.51–2.03) | 0.91 | 0.92 |
| BMI in the 30s | ||||||||||||
| Normalc | 298/328 | 1.00 (Referent) | – | – | 122/94 | 1.00 (Referent) | – | – | 176/234 | 1.00 (Referent) | – | – |
| Overweight | 87/97 | 0.87 (0.58–1.31) | 0.51 | – | 65/64 | 1.01 (0.60–1.71) | 0.96 | – | 22/33 | 0.64 (0.31–1.33) | 0.23 | – |
| Obese | 35/47 | 0.88 (0.46–1.67) | 0.69 | 0.51 | 21/24 | 0.91 (0.37–2.22) | 0.83 | 0.90 | 14/23 | 1.01 (0.39–2.59) | 0.99 | 0.57 |
| BMI in the 20s | ||||||||||||
| Normalc | 346/379 | 1.00 (Referent) | – | – | 155/129 | 1.00 (Referent) | – | – | 191/250 | 1.00 (Referent) | – | – |
| Overweight | 56/71 | 0.71 (0.44–1.15) | 0.16 | – | 41/45 | 0.87 (0.47–1.59) | 0.65 | – | 15/26 | 0.67 (0.29–1.59) | 0.37 | – |
| Obese | 18/22 | 0.69 (0.31–1.55) | 0.37 | 0.13 | 12/8 | 1.31 (0.40–4.29) | 0.65 | 0.81 | 6/14 | 0.42 (0.12–1.44) | 0.17 | 0.11 |
a
Adjusted for age, race, gender, education, income, physical activity, smoking, alcohol, nonsteroidal anti-inflammatory drugs use, and family history of colorectal cancer.
b
Recruitment period: 2 years before recruitment/interview.
c
Normal: ≥18.5 to <25 kg/m2; overweight: ≥25 to <30 kg/m2; obese: ≥30 kg/m2.
*
P value for trend.