Figure 2–13.
Figure 2. Cecum and colon from a TERT-KO mouse. The cecum is contracted, firm, and empty (arrow), the colon and cecal walls are thickened, and the colon contains soft, pasty stool (arrowheads).
Figure 3. Cecum and colon from an unaffected heterozygous control mouse. The cecum is of normal size and the colon contains formed feces.
Figure 4. Cecum of affected TERT-KO mouse. The cecal wall is thickened with inflammatory infiltrate, hyperplastic mucosa-associated lymphoid tissue (arrows), and fibrous connective tissue. HE.
Figure 5. Cecum from an unaffected TERT heterozygous mouse at the same magnification as figure 4. Inflammation is absent. HE.
Figure 6. Cecum from a TERT KO mouse showing replacement of the mucosa by chronic inflammatory infiltrate consisting of granulocytes and mononuclear and multinuclear plasma cells. A retained dysplastic gland is present (arrow). HE
Figure 7. Cecum from a TERT KO mouse. Higher magnification of figure 6 showing dense plasmacytic infiltrate Inset: Multinucleated plasma cell. HE
Figure 8. Cecum from a TERT KO mouse. Higher magnification of figure 6 showing neutrophils and fibrosis in the ulcer crater. HE
Figure 9. Cecum from a TERT KO mouse. Dysplastic glands demonstrate irregular piling up of epithelium with anisocytosis, anisokaryosis, and mild dysplasia. HE
Figure 10. Cecum from a TERT KO mouse. Silver-positive, elongated narrow spiral organisms are present within a cecal gland. Warthin-Starry.
Figure 11. Cecum from a TERT KO mouse. CD3+ cells (a) and CD45R (B220)+ cells (b) are present in association with mucosal lymphoid follicles. IRF-4+ plasma cells (c) account for most of the remaining cells in the lamina propria and submucosa. Inset shows nuclear and cytoplasmic immunoreactivity of both mononuclear and multinuclear plasma cells. There is background staining of most infiltrating lamina propria cells with F4/80 (Interpreted as artifactual, d), and only a few cells have strong membrane staining compatible with macrophages (inset). Immunoperoxidase reaction with DAB (a, b, d) or fast red (c) chromogen and Harris’ hematoxylin counterstain.
Figure 12. Jejunum from a TERT KO mouse showing multifocal adenomatous hyperplasia,. HE.
Figure 13. Jejunum from an unaffected heterozygote control mouse. Adenomatous hyperplasia is absent. HE.