Table 3. Logistic Regression for Outcome Complete Pathologic Response (Yes v. No).
pCR | Univariate Logistic Regression | |||||
---|---|---|---|---|---|---|
N | N | % pCR | OR | 95% CI | p-value | |
Interval from end of NCRT to Surgery | ||||||
Interval in weeks (continuous) | 1.20 | 1.01-1.42 | 0.038 | |||
Log transformation of Interval in weeks(continuous) | 6.77 | 1.32-34.67 | 0.022 | |||
By interval quartiles | ||||||
≤45 Days | 24 | 3 | 12.5 | 1.00 | Ref | |
46-50 Days | 20 | 4 | 20.0 | 1.75 | 0.34-8.95 | 0.50 |
51-63 Days | 22 | 5 | 22.7 | 2.06 | 0.43-9.87 | 0.37 |
64+ Days | 22 | 9 | 40.9 | 4.85 | 1.11-21.26 | 0.036 |
By 3 week intervals | ||||||
3-6 weeks (26-42 days) | 17 | 2 | 11.8 | 1.00 | Ref | |
6.1-9 weeks (43-63 days) | 49 | 10 | 20.4 | 1.92 | 0.38-9.82 | 0.43 |
9.1-12 weeks (64-84 days) | 16 | 6 | 37.5 | 4.50 | 0.75-26.93 | 0.099 |
>12 weeks (85+ days) | 6 | 3 | 50.0 | 7.50 | 0.85-66.12 | 0.070 |
Other Characteristics | ||||||
Age (continuous) | 1.04 | 0.99-1.09 | 0.16 | |||
Gender | ||||||
Female | 13 | 2 | 15.4 | 1.00 | Ref | |
Male | 75 | 19 | 25.3 | 1.87 | 0.38-9.19 | 0.44 |
T Stage | ||||||
T1/T2 | 8 | 2 | 25.0 | 1.00 | Ref | |
T3/T4 | 80 | 19 | 23.8 | 0.93 | 0.17-5.02 | 0.94 |
N Stage | ||||||
Positive | 67 | 16 | 23.9 | 1.00 | 0.99 | |
Negative | 21 | 5 | 23.8 | 1.00 | Ref | |
Mstage | ||||||
M0 | 71 | 19 | 26.8 | 1.00 | Ref | |
Any M1 | 17 | 2 | 11.8 | 0.37 | 0.08-1.75 | 0.21 |
Histology | ||||||
Adenocarcinoma | 74 | 16 | 21.6 | 1.00 | Ref | |
Squamous Cell Carcinoma | 14 | 5 | 35.7 | 2.01 | 0.26 | |
Type of Chemotherapy | ||||||
5FU-based | 71 | 16 | 22.5 | 1.00 | Ref | |
Taxol-based | 17 | 5 | 29.4 | 1.43 | 0.44-4.67 | 0.55 |
Type of RT | ||||||
3D-CRT | 72 | 18 | 25.0 | 1.00 | Ref | |
IMRT | 16 | 3 | 18.8 | 0.69 | 0.18-2.71 | 0.60 |
NCRT: Neoadjuvant chemoradiation
3D-CRT: 3D-conformal radiotherapy
IMRT: intensity modulated radiotherapy