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Identification of ankyrin-B mutations in human probands with cardiac arrhythmia. (A) Domain organization of 220-kDa ankyrin-B with previously identified E1425G mutation and L1622I, T1626N, R1788W, and E1813K mutations denoted. Yellow box denotes death domain, red box denotes C-terminal domain. (B) ECG recordings from European proband with ankyrin-B R1788W mutation. ECG recordings show normal resting ECG and polymorphic ventricular tachycardia induced by exercise.
