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. 2004 Jun 3;101(24):9137–9142. doi: 10.1073/pnas.0402546101

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Copyright © 2004, The National Academy of Sciences

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Fig. 3. — Human ankyrin-B mutations do not restore abnormal spontaneous contractions or abnormal Ca²⁺ dynamics in ankyrin-B^+/- cardiomyocytes. Compared to wild-type cardiomyocytes, ankyrin-B^+/- cardiomyocytes display decreased spontaneous contraction rates (A) and abnormal calcium dynamics (B). Abnormal ankyrin-B^+/- cardiomyocyte contraction rates and calcium dynamics are rescued by transfection of GFP-220-kDa ankyrin-B, but not GFP-220-kDa ankyrin-B mutants E1425G, L1622I, T1626N, R1788W, or E1813K (n > 200 cells; P < 0.05). In B, calcium dynamics (expressed in Hz) were measured by using Fluo-3 AM. (C) Raw data of Ca²⁺ levels in cardiomyocytes (F/F_o). Graphs represent untransfected wild-type and ankyrin-B^+/- neonatal cardiomyocytes and GFP-220-kDa ankyrin-B and GFP-220-kDa ankyrin-B R1788W transfected ankyrin-B^+/- myocytes.