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. 2004 Jun 3;101(24):9137–9142. doi: 10.1073/pnas.0402546101

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Copyright © 2004, The National Academy of Sciences

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Fig. 6. — Reduction of ankyrin-B does not affect Na_v1.5 expression or localization in ankyrin-B^+/- cardiomyocytes. Immunolocalization of endogenous ankyrin-B and Na_v1.5 in wild-type (A) and ankyrin-B^+/- (B) neonatal cardiomyocytes using affinity-purified antibodies. We observed no difference in Na_v1.5 expression or localization between wild-type and ankyrin-B^+/- cardiomyocytes. The perimeter of the cell is outlined in B. Distance between ankyrin-B striations equals 1.8 μm. (C and D) Quantitative Western blot analysis of Na_v1.5 expression in wild-type and ankyrin-B^+/- adult (C) and neonatal (D) cardiomyocytes using ¹²⁵I-labeled protein A. Protein levels were quantitated by PhosphorImaging. Reduction of ankyrin-B levels in ankyrin-B^+/- cardiomyocytes has no affect on Na_v1.5 expression (n = 3, P > 0.05; not significant).