Table 2.
Patients with septic shock included in the meta-analysis
| Authors | Year | Definition of septic shock | Sample size of septic shock | Non-survival of septic shock | Non-survival of albumin group with septic shock (events/total) | Non-survival of crystalloid group with septic shock (events/total) |
|---|---|---|---|---|---|---|
| Rackow et al. [13] | 1983 | Patients were considered septic shock if (1) blood cultures were positive and/or an infected focus was identified, (2) systolic intra-arterial pressure of less than 90 mmHg, or a cardiac index less than 2.2 L/min.m2, or a serum arterial lactate greater than 18 mg/dl, and pulmonary artery wedge pressure less than 15 mmHg. | 18 | 11 | 5/7 | 3/4 |
| Metildi et al. [15] | 1984 | N/A | N/A | N/A | N/A | N/A |
| The SAFE study investigators [6] | 2010 | Septic shock was defined by the presence of a defined focus of infection and at least two of the four systemic inflammatory response syndrome criteria and infection-related cardiovascular sequential organ failure assessment score of 3 or 4. | 438 | 160 | 70/209 | 90/229 |
| The CRISTAL study investigators [14] | 2013 | Septic shock was defined by sepsis induced acute hypovolemia. Hypovolemia was defined by the combination of (1) hypotension: systolic arterial pressure of less than 90 mm Hg, mean arterial pressure of less than 60 mm Hg, orthostatic hypotension, or a delta pulse pressure of 13% or higher; (2) evidence for low filling pressures and low cardiac index as assessed either invasively or noninvasively; and (3) signs of tissue hypoperfusion or hypoxia, including at least two of the following clinical symptoms: a Glasgow coma scale score of less than 12, mottled skin, urinary output of less than 25 mL/h, or capillary refilling time of 3 seconds or longer; and arterial lactate levels higher than 2 mmol/L, blood urea nitrogen higher than 56 mg/dL, or a fractional excretion of sodium of less than 1%. | 1553 | 441 (28-day) 538 (90-day) | 19/59 (28-day) 22/59 (90-day) | 157/557 (28-day) 197/557 (90-day) |
| The ALBIOS study investigators [9] | 2014 | Septic shock was defined by the presence of a defined focus of infection and at least two of the four systemic inflammatory response syndrome criteria and infection-related cardiovascular sequential organ failure assessment score of 3 or 4. | 1121 | 524 (90-day) | 243/558 (90-day) | 281/563 (90-day) |
N/A, not applicable. No detailed description of hemodynamic instability in Metildi et al. [15] trial.