Table 6.
Selected comparisons of the polymorphic variants distribution of tested genes between type 2 DM nephropathy patients, chronic infective tubulointerstitial nephritic patients, and healthy subjects.
| Genotype | Genotype frequencies | Odds ratio (95% CI) | Two-tailed P | P trend | |
|---|---|---|---|---|---|
| Type 2 DM nephropathy versus chronic infective tubulointerstitial nephritis | |||||
| IL18 rs360719 | n = 248 | n = 77 | |||
|
| |||||
| TT | 133 (0.54) | 54 (0.70) | Referent | 0.033 | |
| CT | 102 (0.41) | 19 (0.25) | 2.180 (1.217–3.905) | 0.009a | |
| CC | 13 (0.05) | 4 (0.05) | 1.320 (0.412–4.228) | 0.783 | |
| CT + CC | 115 (0.46) | 23 (0.30) | 2.030 (1.173–3.512) | 0.012a | |
| MAF | 128 (0.26) | 27 (0.18) | 1.636 (1.031–2.596) | 0.046 | |
|
| |||||
| Chronic infective tubulointerstitial nephritis versus healthy controls | |||||
| IL18 rs360719 | n = 77 | n = 240 | |||
|
| |||||
| TT | 54 (0.70) | 121 (0.50) | Referent | 0.005 | |
| CT | 19 (0.25) | 98 (0.41) | 0.434 (0.242–0.781) | 0.006a | |
| CC | 4 (0.05) | 21 (0.09) | 0.427 (0.140–1.303) | 0.160 | |
| CT + CC | 23 (0.30) | 119 (0.50) | 0.433 (0.250–0.750) | 0.004a | |
| MAF | 27 (0.18) | 140 (0.29) | 0.516 (0.326–0.818) | 0.006 | |
DM: diabetes mellitus; MAF: minor allele frequency.
Significant differences are indicated using bold font.
aSignificant after the Bonferroni correction (P < 0.017).