Table 7.
Comparison of the distribution of polymorphic variants of tested genes between ESRD patients treated with hemodialysis due to type 2 DM nephropathy grouped by diagnosis of CAD.
| Parameter | Type 2 DM nephropathy with CAD (frequency) | Type 2 DM nephropathy without CAD (frequency) | Odds ratio (95% CI) | Two-tailed P | P trend |
|---|---|---|---|---|---|
| IL18 rs360719 | n = 124 | n = 109 | |||
|
| |||||
| TT | 68 (0.55) | 53 (0.49) | Referent | 0.269 | |
| CT | 51 (0.41) | 49 (0.45) | 1.128 (0.725–1.754) | 0.653 | |
| CC | 5 (0.04) | 7 (0.06) | 0.628 (0.194–2.036) | 0.557 | |
| CT + CC | 56 (0.45) | 56 (0.51) | 0.879 (0.560–1.380) | 0.645 | |
| MAF | 61 (0.25) | 63 (0.29) | 0.803 (0.532–1.211) | 0.345 | |
|
| |||||
| IL12A rs568408 | n = 117 | n = 102 | |||
|
| |||||
| GG | 83 (0.71) | 77 (0.63) | Referent | 0.361 | |
| AG | 28 (0.24) | 22 (0.22) | 1.181 (0.623–2.236) | 0.630 | |
| AA | 6 (0.05) | 3 (0.03) | 1.855 (0.448–7.678) | 0.502 | |
| AG + AA | 34 (0.29) | 25 (0.25) | 1.262 (0.691–2.304) | 0.542 | |
| MAF | 40 (0.17) | 28 (0.14) | 1.311 (0.776–2.214) | 0.378 | |
|
| |||||
| IL12B rs3212227 | n = 124 | n = 109 | |||
|
| |||||
| AA | 78 (0.63) | 69 (0.63) | Referent | 0.906 | |
| AC | 43 (0.35) | 36 (0.33) | 1.057 (0.611–1.829) | 0.889 | |
| CC | 3 (0.02) | 4 (0.04) | 0.664 (0.143–3.069) | 0.708 | |
| AC + CC | 46 (0.37) | 40 (0.37) | 1.017 (0.597–1.734) | 1.000 | |
| MAF | 49 (0.20) | 44 (0.20) | 0.974 (0.618–1.535) | 0.909 | |
|
| |||||
| IL4R rs1805015 | n = 144 | n = 127 | |||
|
| |||||
| TT | 95 (0.66) | 86 (0.68) | Referent | 0.947 | |
| CT | 42 (0.29) | 32 (0.25) | 1.188 (0.689–2.048) | 0.581 | |
| CC | 7 (0.05) | 9 (0.07) | 0.704 (0.251–1.972) | 0.605 | |
| CT + CC | 49 (0.34) | 41 (0.32) | 1.082 (0.652–1.797) | 0.797 | |
| MAF | 56 (0.19) | 50 (0.20) | 0.985 (0.644–1.504) | 0.944 | |
|
| |||||
| IL13 rs20541 | n = 144 | n = 127 | |||
|
| |||||
| CC | 80 (0.56) | 71 (0.56) | Referent | 0.867 | |
| CT | 55 (0.38) | 46 (0.36) | 1.061 (0.640–1.759) | 0.898 | |
| TT | 9 (0.06) | 10 (0.08) | 0.799 (0.307–2.077) | 0.808 | |
| CT + TT | 64 (0.44) | 56 (0.44) | 1.014 (0.627–1.640) | 1.000 | |
| MAF | 73 (0.25) | 92 (0.26) | 0.967 (0.657–1.423) | 0.944 | |
|
| |||||
| IL28B rs8099917 | n = 163 | n = 145 | |||
|
| |||||
| TT | 105 (0.64) | 97 (0.67) | Referent | 0.752 | |
| GT | 52 (0.32) | 42 (0.29) | 1.144 (0.700–1.870) | 0.618 | |
| GG | 6 (0.04) | 6 (0.04) | 0.924 (0.288–2.961) | 1.000 | |
| GT + GG | 58 (0.36) | 48 (0.33) | 1.116 (0.697–1.189) | 0.719 | |
| MAF | 64 (0.20) | 54 (0.19) | 1.068 (0.714–1.597) | 0.829 | |
|
| |||||
| IL28B rs12979860 | n = 163 | n = 142 | |||
|
| |||||
| CC | 69 (0.42) | 66 (0.46) | Referent | 0.352 | |
| CT | 73 (0.45) | 62 (0.44) | 1.126 (0.698–1.816) | 0.715 | |
| TT | 21 (0.13) | 14 (0.10) | 1.435 (0.674–3.055) | 0.448 | |
| CT + TT | 94 (0.58) | 76 (0.54) | 1.183 (0.752–1.861) | 0.490 | |
| MAF | 115 (0.35) | 90 (0.32) | 1.175 (0.838–1.647) | 0.396 | |
|
| |||||
| GC rs2298849 | n = 172 | n = 158a | |||
|
| |||||
| TT | 99 (0.58) | 106 (0.67) | Referent | 0.173 | |
| CT | 60 (0.35) | 40 (0.25) | 1.606 (0.989–2.608) | 0.067 | |
| CC | 13 (0.07) | 12 (0.08) | 1.160 (0.505–2.663) | 0.833 | |
| CT + CC | 73 (0.42) | 52 (0.33) | 1.503 (0.959–2.355) | 0.088 | |
| MAF | 166 (0.25) | 64 (0.20) | 1.313 (0.909–1.895) | 0.174 | |
|
| |||||
| GC rs7041 | n = 161 | n = 151 | |||
|
| |||||
| GG | 57 (0.35) | 46 (0.30) | Referent | 0.844 | |
| GT | 69 (0.43) | 82 (0.54) | 1.327 (0.825–2.134) | 0.277 | |
| TT | 35 (0.22) | 23 (0.15) | 1.629 (0.900–2.949) | 0.136 | |
| GT + TT | 104 (0.65) | 105 (0.70) | 1.061 (0.721–1.559) | 0.769 | |
| MAF | 139 (0.43) | 128 (0.42) | 1.025 (0.746–1.409) | 0.943 | |
|
| |||||
| GC rs1155563 | n = 172 | n = 157 | |||
|
| |||||
| TT | 82 (0.48) | 79 (0.50) | Referent | 0.645 | |
| CT | 70 (0.41) | 61 (0.39) | 1.106 (0.697–1.755) | 0.724 | |
| CC | 20 (0.12) | 17 (0.11) | 1.133 (0.554–2.321) | 0.856 | |
| CT + CC | 90 (0.52) | 78 (0.50) | 1.112 (0.721–1.714) | 0.660 | |
| MAF | 110 (0.32) | 95 (0.30) | 1.084 (0.779–1.508) | 0.695 | |
|
| |||||
| VDR rs2228570 | n = 162 | n = 152 | |||
|
| |||||
| CC | 43 (0.27) | 44 (0.29) | Referent | 0.316 | |
| CT | 93 (0.57) | 68 (0.45) | 1.400 (0.829–2.363) | 0.230 | |
| TT | 26 (0.16) | 40 (0.26) | 0.665 (0.348–1.272) | 0.252 | |
| CT + TT | 119 (0.73) | 108 (0.71) | 1.128 (0.688–1.849) | 0.705 | |
| MAF | 145 (0.45) | 148 (0.49) | 0.854 (0.624–1.169) | 0.365 | |
|
| |||||
| VDR rs1544410 | n = 170 | n = 155 | |||
|
| |||||
| GG | 65 (0.38) | 61 (0.39) | Referent | 0.772 | |
| AG | 79 (0.46) | 72 (0.46) | 1.030 (0.641–1.653) | 0.905 | |
| AA | 26 (0.15) | 22 (0.14) | 1.109 (0.569–2.160) | 0.865 | |
| AG + AA | 105 (0.62) | 94 (0.61) | 1.048 (0.671–1.639) | 0.909 | |
| MAF | 131 (0.39) | 116 (0.37) | 1.048 (0.763–1.440) | 0.833 | |
|
| |||||
| RXRA rs10776909 | n = 172 | n = 158 | |||
|
| |||||
| CC | 112 (0.65) | 104 (0.66) | Referent | 0.621 | |
| CT | 48 (0.28) | 47 (0.30) | 0.948 (0.585–1.537) | 0.902 | |
| TT | 12 (0.07) | 7 (0.04) | 1.592 (0.604–4.198) | 0.473 | |
| CT + TT | 60 (0.35) | 54 (0.34) | 1.032 (0.655–1.625) | 0.908 | |
| MAF | 72 (0.21) | 61 (0.19) | 1.107 (0.756–1.621) | 0.672 | |
|
| |||||
| RXRA rs10881578 | n = 173 | n = 158 | |||
|
| |||||
| AA | 89 (0.51) | 92 (0.58) | Referent | 0.192 | |
| AG | 65 (0.38) | 53 (0.34) | 1.268 (0.796–2.019) | 0.345 | |
| GG | 19 (0.11) | 13 (0.08) | 1.511 (0.704–3.241) | 0.340 | |
| AG + GG | 84 (0.49) | 66 (0.42) | 1.316 (0.852–2.032) | 0.226 | |
| MAF | 103 (0.30) | 79 (0.25) | 1.272 (0.902–1.793) | 0.199 | |
|
| |||||
| RXRA rs749759 | n = 169 | n = 153 | |||
|
| |||||
| GG | 100 (0.59) | 89 (0.58) | Referent | 0.812 | |
| AG | 59 (0.35) | 54 (0.35) | 0.972 (0.610–1.551) | 1.000 | |
| AA | 10 (0.06) | 10 (0.07) | 0.890 (0.354–2.238) | 0.818 | |
| AG + AA | 69 (0.41) | 64 (0.42) | 0.960 (0.615–1.496) | 0.910 | |
| MAF | 79 (0.23) | 74 (0.24) | 0.956 (0.665–1.375) | 0.882 | |
CAD: coronary artery disease, ESRD: end-stage renal disease, DM: diabetes mellitus, and MAF: minor allele frequency.
aNot consistent with Hardy-Weinberg equilibrium.