Table 8.
Comparison of the distribution of polymorphic variants of tested genes between type 2 DM nephropathy patients with diagnosis of CAD and healthy controls.
| Parameter | Type 2 DM nephropathy with CAD (frequency) | Healthy controls (frequency) | Odds ratio (95% CI) | Two-tailed P | P trend |
|---|---|---|---|---|---|
| IL18 rs360719 | n = 124 | n = 240 | |||
|
| |||||
| TT | 68 (0.55) | 121 (0.50) | Referent | 0.186 | |
| CT | 51 (0.41) | 98 (0.41) | 0.926 (0.590–1.453) | 0.819 | |
| CC | 5 (0.04) | 21 (0.09) | 0.424 (0.153–1.174) | 0.122 | |
| CT + CC | 56 (0.45) | 119 (0.50) | 0.837 (0.542–1.294) | 0.440 | |
| MAF | 61 (0.25) | 140 (0.29) | 0.792 (0.558–1.124) | 0.223 | |
|
| |||||
| IL12A rs568408 | n = 117 | n = 240 | |||
|
| |||||
| GG | 83 (0.71) | 171 (0.71) | Referent | 0.626 | |
| AG | 28 (0.24) | 63 (0.26) | 0.916 (0.546–1.535) | 0.794 | |
| AA | 6 (0.05) | 6 (0.03) | 2.060 (0.645–6.583) | 0.348 | |
| AG + AA | 34 (0.29) | 69 (0.29) | 1.015 (0.624–1.653) | 1.000 | |
| MAF | 40 (0.17) | 75 (0.16) | 1.113 (0.731–1.695) | 0.695 | |
|
| |||||
| IL12B rs3212227 | n = 124 | n = 240 | |||
|
| |||||
| AA | 78 (0.63) | 151 (0.63) | Referent | 0.475 | |
| AC | 43 (0.35) | 77 (0.32) | 1.081 (0.681–1.717) | 0.813 | |
| CC | 3 (0.02) | 12 (0.05) | 0.484 (0.133–1.766) | 0.397 | |
| AC + CC | 46 (0.37) | 89 (0.37) | 1.001 (0.639–1.567) | 1.000 | |
| MAF | 49 (0.20) | 101 (0.21) | 0.924 (0.631–1.354) | 0.757 | |
|
| |||||
| IL4R rs1805015 | n = 144 | n = 225 | |||
|
| |||||
| TT | 95 (0.66) | 162 (0.72) | Referent | 0.285 | |
| CT | 42 (0.29) | 53 (0.24) | 1.351 (0.838–2.179) | 0.221 | |
| CC | 7 (0.05) | 10 (0.04) | 1.194 (0.440–3.240) | 0.798 | |
| CT + CC | 49 (0.34) | 63 (0.28) | 1.326 (0.845–2.083) | 0.246 | |
| MAF | 56 (0.19) | 73 (0.16) | 1.247 (0.848–1.832) | 0.305 | |
|
| |||||
| IL13 rs20541 | n = 144 | n = 230 | |||
|
| |||||
| CC | 80 (0.56) | 124 (0.54) | Referent | 0.469 | |
| CT | 55 (0.38) | 84 (0.36) | 1.015 (0.653–1.578) | 1.000 | |
| TT | 9 (0.06) | 22 (0.10) | 0.634 (0.278–1.447) | 0.324 | |
| CT + TT | 64 (0.44) | 106 (0.46) | 0.936 (0.616–1.422) | 0.831 | |
| MAF | 73 (0.25) | 128 (0.28) | 0.881 (0.630–1.231) | 0.510 | |
|
| |||||
| IL28B rs8099917 | n = 163 | n = 375 | |||
|
| |||||
| TT | 105 (0.64) | 245 (0.65) | Referent | 0.584 | |
| GT | 52 (0.32) | 123 (0.33) | 0.986 (0.663–1.467) | 1.000 | |
| GG | 6 (0.04) | 7 (0.02) | 2.000 (0.656–6.094) | 0.229 | |
| GT + GG | 58 (0.36) | 130 (0.35) | 1.041 (0.709–1.530) | 0.845 | |
| MAF | 64 (0.20) | 137 (0.18) | 1.093 (0.786–1.521) | 0.658 | |
|
| |||||
| IL28B rs12979860 | n = 163 | n = 372 | |||
|
| |||||
| CC | 69 (0.42) | 164 (0.44) | Referent | 0.281 | |
| CT | 73 (0.45) | 166 (0.45) | 1.045 (0.705–1.549) | 0.841 | |
| TT | 21 (0.13) | 42 (0.11) | 1.188 (0.656–2.154) | 0.644 | |
| CT + TT | 94 (0.58) | 208 (0.56) | 1.074 (0.740–1.558) | 0.776 | |
| MAF | 115 (0.35) | 250 (0.34) | 1.077 (0.819–1.416) | 0.644 | |
|
| |||||
| GC rs2298849 | n = 172 | n = 375 | |||
|
| |||||
| TT | 99 (0.58) | 237 (0.63) | Referent | 0.080 | |
| CT | 60 (0.35) | 124 (0.33) | 1.158 (0.786–1.706) | 0.486 | |
| CC | 13 (0.07) | 14 (0.04) | 2.223 (1.008–4.901) | 0.052 | |
| CT + CC | 73 (0.42) | 138 (0.37) | 1.266 (0.876–1.830) | 0.220 | |
| MAF | 166 (0.25) | 152 (0.20) | 1.311 (0.969–1.774) | 0.092 | |
|
| |||||
| GC rs7041 | n = 161 | n = 361 | |||
|
| |||||
| GG | 57 (0.35) | 116 (0.32) | Referent | 0.748 | |
| GT | 69 (0.43) | 186 (0.52) | 0.755 (0.496–1.150) | 0.196 | |
| TT | 35 (0.22) | 59 (0.16) | 1.207 (0.714–2.040) | 0.502 | |
| GT + TT | 104 (0.65) | 245 (0.68) | 0.864 (0.584–1.278) | 0.482 | |
| MAF | 139 (0.43) | 304 (0.42) | 1.044 (0.801–1.362) | 0.800 | |
|
| |||||
| GC rs1155563 | n = 172 | n = 377 | |||
|
| |||||
| TT | 82 (0.48) | 189 (0.50) | Referent | 0.378 | |
| CT | 70 (0.41) | 155 (0.41) | 1.041 (0.710–1.527) | 0.845 | |
| CC | 20 (0.12) | 33 (0.09) | 1.397 (0.757–2.578) | 0.332 | |
| CT + CC | 90 (0.52) | 188 (0.50) | 1.103 (0.769–1.583) | 0.646 | |
| MAF | 110 (0.32) | 221 (0.29) | 1.134 (0.861–1.494) | 0.411 | |
|
| |||||
| VDR rs2228570 | n = 162 | n = 371 | |||
|
| |||||
| CC | 43 (0.27) | 103 (0.28) | Referent | 0.386 | |
| CT | 93 (0.57) | 183 (0.49) | 1.217 (0.788–1.880) | 0.384 | |
| TT | 26 (0.16) | 85 (0.23) | 0.733 (0.416–1.290) | 0.321 | |
| CT + TT | 119 (0.73) | 268 (0.72) | 1.064 (0.702–1.613) | 0.833 | |
| MAF | 145 (0.45) | 353 (0.48) | 0.893 (0.687–1.160) | 0.434 | |
|
| |||||
| VDR rs1544410 | n = 170 | n = 372 | |||
|
| |||||
| GG | 65 (0.38) | 148 (0.40) | Referent | 0.880 | |
| AG | 79 (0.46) | 165 (0.44) | 1.090 (0.734–1.620) | 0.687 | |
| AA | 26 (0.15) | 59 (0.16) | 1.003 (0.581–1.732) | 1.000 | |
| AG + AA | 105 (0.62) | 224 (0.60) | 1.067 (0.735–1.549) | 0.776 | |
| MAF | 131 (0.39) | 283 (0.38) | 1.021 (0.784–1.329) | 0.931 | |
|
| |||||
| RXRA rs10776909 | n = 172 | n = 378 | |||
|
| |||||
| CC | 112 (0.65) | 250 (0.66) | Referent | 0.483 | |
| CT | 48 (0.28) | 112 (0.30) | 0.957 (0.638–1.434) | 0.838 | |
| TT | 12 (0.07) | 16 (0.04) | 1.674 (0.767–3.656) | 0.209 | |
| CT + TT | 60 (0.35) | 128 (0.34) | 1.046 (0.716–1.529) | 0.846 | |
| MAF | 72 (0.21) | 144 (0.19) | 1.125 (0.819–1.545) | 0.518 | |
|
| |||||
| RXRA rs10881578 | n = 173 | n = 377 | |||
|
| |||||
| AA | 89 (0.51) | 183 (0.48) | Referent | 0.682 | |
| AG | 65 (0.38) | 154 (0.41) | 0.868 (0.591–1.275) | 0.494 | |
| GG | 19 (0.11) | 40 (0.11) | 0.977 (0.535–1.783) | 1.000 | |
| AG + GG | 84 (0.49) | 194 (0.51) | 0.890 (0.621–1.276) | 0.582 | |
| MAF | 103 (0.30) | 234 (0.31) | 0.942 (0.714–1.243) | 0.725 | |
|
| |||||
| RXRA rs749759 | n = 169 | n = 370 | |||
|
| |||||
| GG | 100 (0.59) | 221 (0.60) | Referent | 0.924 | |
| AG | 59 (0.35) | 123 (0.33) | 1.060 (0.718–1.566) | 0.842 | |
| AA | 10 (0.06) | 26 (0.07) | 0.850 (0.395–1.830) | 0.710 | |
| AG + AA | 69 (0.41) | 149 (0.40) | 1.023 (0.707–1.482) | 0.925 | |
| MAF | 79 (0.23) | 175 (0.24) | 0.985 (0.727–1.334) | 0.983 | |
CAD: coronary artery disease, DM: diabetes mellitus, and MAF: minor allele frequency.